Digestive Health & Nausea > Motilium (Generic)

Motilium (Generic)
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Motilium (Domperidone) Description

Domperidone, offered under the brand Motilium amongst others, is a peripherally discerning dopamine D2 receptor villain that was created by Janssen Pharmaceutica as well as is utilized as an antiemetic, gastroprokinetic agent, as well as galactagogue. Common Domperidone (Motilium (Domperidone)) is an antidopaminergic medication that is prescribed to surpress the sensations of nausea as well as retching. Motilium is made use of to supress nausea or vomiting and vomiting, and acts mainly by blocking dopamine receptors discovered in the top end of the digestion system. This triggers tightening up of the muscles at the access to the stomach, leisure of the muscular tissues at the end point of the tummy and enhanced contraction of the muscular tissues in the belly itself. These activities quicken the passage of food through the stomach into the intestine, which physically helps stop vomiting and minimizes sensations of health issues, bloating and bellyful. You should take Generic Motilium pills with a cup of water 15 to Thirty Minutes prior to meals. If you more than 16, you could take a pill 3 times every day as well as before going to bed. To increase breastmilk the dose advised by lactation experts can be increased to 2 tablets 4 times every day. Negative effects consist of: allergic reactions, including rash or urticaria; stomach cramps; dystonic responses (extrapyramidal sensations). Relatively easy to fix raised serum prolactin levels have been observed which may cause galactorrhoea as well as gynaecomastia.

How to buy Motilium

Buying Motilium online with our drug store solution is fast and also very simple. Nevertheless you ought to take your treatment with a great care. Attempt to consult with your physician prior to deciding to purchase it. Even if you believe the information above suffices for you to decide, medical consultation is a must to prevent serious side effects.

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Product Info

Uses

Generic Motilium is used to supress nausea and vomiting, and works primarily by blocking dopamine receptors found in the upper end of the digestive system. This causes tightening of the muscles at the entry to the stomach, relaxation of the muscles at the exit of the stomach and increased contraction of the muscles in the stomach itself. These actions speed up the passage of food through the stomach into the intestine, which physically helps prevent vomiting and reduces feelings of sickness, bloating and fullness. It also prevents food from flowing the wrong way through the stomach and so prevents reflux (regurgitation of the stomach contents back into the foodpipe).

How to take

You should take Generic Motilium tablets with a glass of water 15 to 30 minutes before meals. If you are over 16, you can take a tablet three times a day and at bedtime. To increase breastmilk the dosage recommended by lactation consultants is up to TWO tablets FOUR times a day.

Side effects

Side effects include:

  • Allergic reactions, such as rash or urticaria.
  • Abdominal cramps.
  • Dystonic reactions (extrapyramidal phenomena) may occur.
  • Reversible raised serum prolactin levels have been observed which may lead to galactorrhoea and gynaecomastia.
  • Hypertensive crises in patient.

 

Precautions

Since domperidone is highly metabolised in the liver, domperidone should be used with caution in patients with hepatic impairment (and in the elderly).

Domperidone should be used with caution in patients with renal impairment or in those at risk of fluid retention. In patients with severe renal insufficiency (serum creatinine more than 6mg/100ml, i.e. more than 0,6mmol/L) the elimination half-life of domperidone was increased from 7,4 to 20,8 hours. The dosing frequency should be reduced to once or twice daily, depending on the severity of impairment, and the dose may need to be reduced. Patients on prolonged therapy should be reviewed regularly.

Drug interactions

Antacids and anti-secretory agents lower the oral bioavailability of domperidone. They should be taken after meals and not before meals, i.e. they should not be taken simultaneously with domperidone.

Reduced gastric acidity impairs the absorption of domperidone.

Oral bioavailability is decreased by prior administration of cimetidine or sodium bicarbonate.

The main metabolic pathway of domperidone is through CYP3A4. In vitro data suggests that concomitant use of drugs that significantly inhibit this enzyme may result in increased plasma levels of domperidone.

Examples of CYP3A4 inhibitors include the following:

  • azole antifungals
  • macrolide antibiotics
  • HIV protease inhibitors
  • nefazodone

Missed dose

If you miss a dose of Generic Motilium, take it as soon as you remember, unless it is time to take the next dose, then skip the missed dose. Do not take a double dose.

Storage

Store below 25 degrees Celsius, away from moisture and sunlight. Do not store in the bathroom. Keep away from children and pets.